The research team led by Prof. Alon Monsonego mapped immune-cell profiles from centenarians and identified a subgroup of T helper cells (TH-X) whose gene signatures correlate with longevity and preserved immunity. Unlike standard helper subsets, TH-X express unique surface markers and produce cytokines that trigger removal of senescent cells, reducing chronic inflammation—a hallmark of aging. Their prevalence in very old yet healthy individuals suggests potential translational value.
While still early, the findings open opportunities for immunotherapy aimed at boosting TH-X populations or mimicking their effects. Challenges remain: ensuring safety, specificity and long-term outcomes in human trials. Nonetheless, the study offers one of the most promising immune-aging links to emerge recently.
NEW SUBSET OF T HELPER CELLS MAY SLOW AGING, STUDY FINDS
